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Descriptive epidemiology of pediatric intracranial neoplasms in Egypt

Mohamed Ali El-Gaidi1

  • 1Department of Neurosurgery, Kasr Al-Ainy Medical School, Cairo University, Cairo, Egypt. mohamedelgaidi@gmail.com

Pediatric Neurosurgery
|July 11, 2012
PubMed

Insights

This study analyzed 451 Egyptian children with primary intracranial neoplasms. Pediatric brain tumor characteristics in Egypt align with global data, showing slight male predominance and common astrocytomas.

Area of Science:

  • Pediatric Neurosurgery
  • Neuro-oncology
  • Epidemiology of Childhood Cancers

Background:

  • Primary intracranial neoplasms in children present unique diagnostic and therapeutic challenges.
  • Understanding the epidemiological and pathological characteristics of these tumors is crucial for improving patient outcomes.
  • Previous studies have highlighted variations in pediatric brain tumor profiles across different geographic regions.

Purpose of the Study:

  • To investigate the demographic, clinical, topographical, and pathological features of primary intracranial neoplasms in Egyptian children.
  • To characterize the spectrum of pediatric brain tumors based on the 2007 Classification of Central Nervous System Tumors.
  • To compare the findings with existing international literature on childhood brain tumors.

Main Methods:

  • A retrospective analysis of 451 Egyptian children (aged 0-14 years) diagnosed with primary intracranial neoplasms.
  • Data collected from 2005 to 2008 at Cairo University Hospitals.
  • Tumor classification utilized the 2007 Classification of Central Nervous System Tumors and ICD-O-4 coding.

Main Results:

  • A slight male predominance (51.4%) was observed, with the 5-9 year age group most affected (43.2%).
  • Infratentorial (49.7%) and supratentorial (46.6%) locations were most common.
  • Astrocytomas (35%), medulloblastomas (18.8%), craniopharyngiomas (11.3%), and ependymomas (10%) were the most frequent diagnoses. Benign, borderline, and malignant tumors comprised 7.54%, 36.14%, and 56.32% respectively.

Conclusions:

  • The epidemiological and pathological characteristics of pediatric intracranial tumors in Egypt are broadly consistent with international findings.
  • Minor variations exist, emphasizing the need for continued regional surveillance and research.
  • This study provides valuable data on the burden and nature of childhood brain tumors in Egypt.
Abstract

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