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Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

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Erythrocyte n-3 polyunsaturated fatty acid and seafood intake decrease the risk of depression: case-control study in

Yongsoon Park¹, Malgeunsinae Kim, Dawon Baek

¹Department of Food and Nutrition, Hanyang University, Seoul, Korea. yongsoon@hanyang.ac.kr

Annals of Nutrition & Metabolism

|July 11, 2012

Summary

Increased erythrocyte levels of omega-3 polyunsaturated fatty acids (PUFA) and seafood intake are linked to a lower risk of depression in Koreans. Conversely, higher trans fatty acid levels correlate with increased depression risk.

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Area of Science:

Nutritional Neuroscience
Psychiatry
Epidemiology

Background:

Low n-3 polyunsaturated fatty acid (PUFA) intake or tissue levels are linked to increased depression risk, though findings are inconsistent.
This study investigates the association between erythrocyte n-3 PUFA levels, seafood intake, and depression risk in a Korean population.

Purpose of the Study:

To evaluate the hypothesis that higher erythrocyte levels of n-3 PUFA and greater seafood consumption are associated with a reduced risk of depression.
To examine the relationship between specific fatty acid profiles in erythrocytes and depression risk.

Main Methods:

Case-control study involving 80 Korean patients diagnosed with depression (Center for Epidemiological Studies Depression Scale score ≥25).
88 age- and sex-matched controls without chronic diseases were recruited.
Multivariate-adjusted regression analysis was used to assess associations.

Main Results:

Depression risk was negatively associated with erythrocyte levels of 20:5 n-3, 22:6 n-3 (omega-3 PUFAs), 16:0, and 18:0 (saturated fatty acids).
Conversely, depression risk was positively associated with erythrocyte levels of 18:2t and 16:1 (trans and monounsaturated fatty acids).
Higher intake of energy, carbohydrate, seafood, and grains was associated with lower depression risk, while higher fat and meat intake correlated with increased risk.

Conclusions:

Increased erythrocyte levels of n-3 PUFA and saturated fatty acids, along with higher seafood intake, may decrease depression risk in Koreans.
Lower erythrocyte levels of trans fatty acids are associated with a reduced risk of depression.
Dietary patterns rich in seafood and certain fatty acids may play a protective role against depression.