Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-trajectories of intrinsic capacity and their impact on incident disability in community-dwelling older adults in Japan.

Archives of gerontology and geriatrics·2026
Same author

Ten-year longitudinal effects of physical activity and apolipoprotein E ..4 genotype on precuneus atrophy in Japanese older adults.

Archives of gerontology and geriatrics·2026
Same author

Higher openness and conscientiousness are associated with lower risk of long-term care needs: A 22-year follow-up of community-dwelling older adults in Japan.

Experimental gerontology·2026
Same author

A frailty-intrinsic capacity index to predict disability in community-dwelling older Japanese adults.

JAR life·2025
Same author

Risk factors associated with cognitive frailty development through different transition pathways among community-dwelling older adult Japanese individuals: insights from the NILS-LSA project.

BMC geriatrics·2025
Same author

Longitudinal Changes in Corneal Thickness over 8 Years: Findings from the National Institute for Longevity Sciences-Longitudinal Study of Aging Population-Based Cohort Study in Japan.

Ophthalmology science·2025

Related Experiment Video

Updated: May 20, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Relationship between physical activity and brain atrophy progression.

Atsumu Yuki1, Sungchul Lee, Heungyoul Kim

  • 1Department for Development of Preventive Medicine, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu City, Aichi Prefecture, Japan. ats.yuki.73@gmail.com

Medicine and Science in Sports and Exercise
|July 11, 2012
PubMed
Summary

Daily physical activity, measured by energy expenditure and steps, significantly predicts reduced frontal lobe atrophy in men over 8 years. Promoting physical activity may help prevent dementia.

More Related Videos

Orienteering as a Tool for Cognitive Research: An Implementation Guide
07:13

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Published on: November 29, 2024

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

Related Experiment Videos

Last Updated: May 20, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Orienteering as a Tool for Cognitive Research: An Implementation Guide
07:13

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Published on: November 29, 2024

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

Area of Science:

  • Neuroscience
  • Gerontology
  • Public Health

Background:

  • Brain atrophy is linked to cognitive and learning impairments.
  • Age-related brain atrophy is a significant concern for cognitive health.

Purpose of the Study:

  • To investigate if daily physical activity can prevent age-related brain atrophy progression.
  • To assess the association between physical activity levels and brain atrophy.

Main Methods:

  • Longitudinal study of 774 participants (381 men, 393 women) over 8.2 years.
  • Magnetic resonance imaging (MRI) of frontal and temporal lobes at baseline and follow-up.
  • Physical activity and energy expenditure measured using accelerometry; logistic regression used for analysis.

Main Results:

  • Higher physical activity (energy expenditure, steps) was associated with lower frontal lobe atrophy progression in men.
  • Low total energy expenditure increased risk for frontal lobe atrophy progression in both men and women.
  • No significant association found between physical activity and temporal lobe atrophy progression.

Conclusions:

  • Physical activity and energy expenditure are key predictors of frontal lobe atrophy progression over 8 years.
  • Encouraging physical activity may mitigate age-related frontal lobe atrophy.
  • Interventions promoting physical activity could aid in dementia prevention.