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Tumour molecular profiling for deciding therapy-the French initiative

Frédérique Nowak1, Jean-Charles Soria, Fabien Calvo

  • 1Institut National du Cancer, 52 Avenue André Morizet, Boulogne Billancourt 92153, France.

Nature Reviews. Clinical Oncology
|July 11, 2012
PubMed

Insights

France established a national network of molecular genetics centers to provide free tumor molecular profiling for cancer patients. This initiative ensures equitable access to predictive tests and targeted therapies, proving cost-effective.

Area of Science:

  • Oncology
  • Genetics
  • Public Health

Background:

  • Therapeutic decisions increasingly rely on tumor molecular profiles, necessitating integration of molecular diagnostics into routine clinical practice.
  • Unequal access to molecular testing and targeted therapies presents a significant challenge in cancer care.

Approach:

  • Established a national network of 28 regional molecular genetics centers across France.
  • Provides selected molecular tests free of charge to all regional cancer patients, irrespective of treatment institution.
  • Implemented a program to expedite access to new targeted treatments and experimental therapies.

Key Points:

  • In 2011, 55,000 cancer patients in France received molecular predictive tests.
  • The nationwide initiative combats inequalities in accessing molecular diagnostics and personalized medicine.
  • Molecular stratification of tumors is a cost-effective strategy integrated into the healthcare system.

Conclusions:

  • France's national initiative successfully integrates molecular profiling into routine cancer care.
  • The program demonstrates the feasibility and cost-effectiveness of molecularly guided therapy.
  • This model promotes equitable access to advanced cancer diagnostics and treatments nationwide.

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