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Related Concept Videos

Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Vaccinations01:51

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Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Steps in Outbreak Investigation01:18

Steps in Outbreak Investigation

In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:

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Efficient Transfection of In vitro Transcribed mRNA in Cultured Cells Using Peptide-Poloxamine Nanoparticles
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Accelerated vaccine development against emerging infectious diseases.

Pierre R Leblanc1, Jianping Yuan, Tim Brauns

  • 1Vaccine and Immunotherapy Center, Infectious Diseases Medicine, Massachusetts General Hospital, Charlestown, MA, USA.

Human Vaccines & Immunotherapeutics
|July 11, 2012
PubMed
Summary

Developing rapid and flexible vaccine technologies is crucial for emerging infectious diseases. A new collaborative approach combines "-omics" and vaccinology to accelerate vaccine deployment and prevent pandemics.

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Area of Science:

  • * Infectious disease research
  • * Vaccinology and immunology
  • * Biotechnology and bioinformatics

Background:

  • * Emerging and re-emerging infectious diseases pose significant global health threats.
  • * Traditional vaccine development timelines are often insufficient for rapid response.
  • * Balancing speed and rigorous standards in vaccine creation presents a challenge.

Purpose of the Study:

  • * To describe a novel consortium approach for accelerated vaccine development.
  • * To integrate advanced technologies like '-omics' with vaccinology.
  • * To establish a new standard for timely vaccine deployment against pandemics.

Main Methods:

  • * Collaboration between five academic and industrial organizations.
  • * Application of '-omics' technologies (genomics, proteomics, etc.).
  • * Integration of modern vaccinology principles and platforms.

Main Results:

  • * A framework for rapid and flexible vaccine generation has been developed.
  • * The approach facilitates technologies and processes for accelerated regulatory review.
  • * Successful integration of interdisciplinary expertise from academia and industry.

Conclusions:

  • * This novel approach addresses the dual needs of speed and regulatory compliance in vaccine development.
  • * The consortium's strategy has the potential to become a new standard in the field.
  • * Timely deployment of vaccines can be achieved to avert potential pandemics.