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Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

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Roxithromycin-induced toxic epidermal necrolysis.

Saibal Das¹, Somnath Mondal, Jayanta Kumar Dey

¹General Emergency, NRS Medical College and Hospital, Kolkata, India. saibaldas123@gmail.com

Therapeutic Drug Monitoring

|July 11, 2012

Summary

This summary is machine-generated.

A rare case of toxic epidermal necrolysis (TEN), a severe skin reaction, was reported in a patient taking oral roxithromycin. Prompt discontinuation of the drug led to the patient's recovery.

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Area of Science:

Pharmacology
Dermatology
Clinical Medicine

Background:

Adverse drug reactions (ADRs) pose significant challenges in clinical practice.
Macrolide antibiotics, like roxithromycin, are commonly prescribed for respiratory infections.
Toxic epidermal necrolysis (TEN) is a rare but life-threatening mucocutaneous reaction.

Observation:

A 54-year-old male developed severe skin lesions, including painful blisters covering over 30% of his body surface area.
Symptoms included sore throat, ocular irritation, and painful urination, appearing 10 days after initiating oral roxithromycin.
Clinical, laboratory, and histopathological findings confirmed TEN, with no other contributing factors identified.

Findings:

The case report strongly suggests oral roxithromycin as the probable cause of TEN.
The Naranjo scale indicated a probable association between roxithromycin and the adverse drug reaction.
Immediate cessation of roxithromycin and supportive care resulted in patient recovery.

Implications:

This case underscores the importance of vigilance for rare but severe ADRs associated with commonly used antibiotics.
Healthcare providers should consider roxithromycin as a potential trigger for TEN in patients presenting with characteristic symptoms.
Further pharmacovigilance is crucial to identify and mitigate risks associated with macrolide antibiotics.