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Ascorbic acid prevents cimetidine-induced decrease of serum hydrocortisone concentrations.

M P Boidin1, A Stuurman, W Erdmann

  • 1Department of Anaesthesiology, Erasmus University Rotterdam, The Netherlands.

Pharmaceutisch Weekblad. Scientific Edition
|August 24, 1990
PubMed
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Ascorbic acid (vitamin C) can prevent a decrease in human serum hydrocortisone levels caused by cimetidine. This study found vitamin C helps maintain normal hydrocortisone profiles in surgical patients.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Clinical Medicine

Background:

  • Cimetidine administration can inhibit steroidogenesis, leading to decreased serum hydrocortisone concentrations.
  • Cytochrome P-450 plays a crucial role in steroidogenesis, and cimetidine can block its active site.
  • Reduced hydrocortisone levels can disrupt normal physiological processes, particularly in surgical patients.

Purpose of the Study:

  • To investigate the effect of ascorbic acid on human serum hydrocortisone concentrations.
  • To determine if ascorbic acid can counteract the hydrocortisone-lowering effect of cimetidine.
  • To assess the impact of ascorbic acid on hydrocortisone profiles in surgical patients under anesthesia.

Main Methods:

  • A blind, parallel, prospective clinical study was conducted.

Related Experiment Videos

  • Participants included 16 male adults undergoing major abdominal vascular surgery.
  • Patients received either ascorbic acid or a placebo, alongside cimetidine, under anesthesia.

    • Main Results:

    • Patients receiving a placebo showed a reduction in serum hydrocortisone.
    • Patients receiving ascorbic acid demonstrated a significant increase in serum hydrocortisone concentration.
    • Ascorbic acid administration appeared to restore the normal hydrocortisone profile for the surgical procedure.

    Conclusions:

    • Ascorbic acid can prevent the decrease in human serum hydrocortisone concentrations induced by cimetidine.
    • The findings suggest a potential therapeutic role for ascorbic acid in managing cimetidine-induced hormonal changes.
    • Further research is needed to elucidate the exact mechanisms by which ascorbic acid exerts this effect.