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Updated: May 20, 2026

The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation

The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation

Published on: August 15, 2018

Neonatal non-invasive respiratory support: physiological implications.

Thomas H Shaffer¹, Deepthi Alapati, Jay S Greenspan

¹Nemours Center for Pediatric Lung Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA. tshaffer@nemours.org

Pediatric Pulmonology

|July 11, 2012

Summary

This summary is machine-generated.

Assisted ventilation saves neonates but causes chronic lung injury, known as bronchopulmonary dysplasia. This review explores non-invasive respiratory support to prevent invasive mechanical ventilation

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The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation

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Published on: August 15, 2018

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

Area of Science:

Neonatal Medicine
Pulmonology
Critical Care

Background:

Assisted ventilation has improved survival for neonatal pulmonary insufficiency.
However, invasive mechanical ventilation is linked to increased morbidity, including bronchopulmonary dysplasia.
Bronchopulmonary dysplasia presents as chronic lung injury with ventilator dependence and neurodevelopmental issues.

Purpose of the Study:

To review non-invasive respiratory support methodologies.
To explore the physiologic mechanisms by which non-invasive methods may prevent invasive ventilation's adverse effects.

Main Methods:

Literature review of non-invasive respiratory support techniques.
Analysis of pathophysiologic mechanisms in neonatal lung injury.

Main Results:

Non-invasive methods offer potential to mitigate lung injury.
Understanding physiologic mechanisms is key to preventing bronchopulmonary dysplasia.

Conclusions:

Non-invasive respiratory support is a promising strategy to reduce morbidity associated with neonatal respiratory care.
Further research into non-invasive techniques can improve long-term outcomes for high-risk neonates.