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Updated: May 20, 2026
Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides
Published on: July 14, 2015
Protein conformational studies for macromolecularly imprinted polymers
David R Kryscio1, Michael Q Fleming, Nicholas A Peppas
1Fletcher Stuckey Pratt Chair in Engineering, Departments of Chemical Engineering and Biomedical Engineering, University of Texas at Austin, 1 University Station C0400, Austin, TX 78712-1062, USA.
Abstract:
CD is used to clearly show the negative impact of common ligands on the overall conformation of BSA, a typical protein template in macromolecularly imprinted polymers. This change occurs at concentrations far lower than those generally used in the literature. These findings are important as they offer insight into a potential fundamental reason for the lack of success in protein imprinting to date despite significant interest from the scientific community.
