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Related Experiment Video

Updated: May 20, 2026

A Naturalistic Setup for Presenting Real People and Live Actions in Experimental Psychology and Cognitive Neuroscience Studies

A Naturalistic Setup for Presenting Real People and Live Actions in Experimental Psychology and Cognitive Neuroscience Studies

Published on: August 4, 2023

Choriophobia: a 1-act play.

James A Taylor¹, Douglas J Opel

¹Department of Pediatrics, University of Washington, Box 354920, Seattle, WA 98195-4920, USA. uncjat@u.washington.edu

|July 11, 2012

Summary

Newborns born to mothers with chorioamnionitis and negative Group B Streptococcus screening have a low sepsis risk (<1%). Current guidelines for treating these infants with antibiotics may need reevaluation due to low risk and ethical considerations.

Area of Science:

Neonatal care
Infectious disease epidemiology
Maternal-fetal medicine

Background:

Management of neonates born to mothers with chorioamnionitis is debated.
Routine maternal screening for Group B Streptococcus (GBS) is standard practice.

Purpose of the Study:

To assess the risk of early-onset sepsis in term infants born to mothers with chorioamnionitis and negative GBS screening.
To evaluate current guidelines recommending universal antibiotic treatment for such neonates.

Main Methods:

Utilized data from neonates born during the era of routine maternal GBS screening.
Calculated the risk of early-onset sepsis in a hypothetical term infant with specific maternal and infant characteristics.

Main Results:

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The calculated risk of early-onset sepsis in term infants born to mothers with chorioamnionitis and negative GBS screen, with normal physical exams, is substantially less than 1%.
This low risk challenges the necessity of current guidelines recommending 48-hour intravenous antibiotic treatment pending blood culture results.

Conclusions:

Current guidelines for treating neonates born to mothers with chorioamnionitis may overtreat infants with very low sepsis risk.
The recommendation for universal antibiotic treatment raises ethical questions about defining unacceptable newborn risk, necessitating broader societal deliberation beyond expert consensus.