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Related Experiment Video

Updated: May 20, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Piperacillin/tazobactam induced thrombocytopaenia--a delayed response.

Jessica L Macwilliam¹, Rahul Mistry, Michael S Floyd

¹Urology Department, Aintree University Hospital, Liverpool, UK. jmac@doctors.org.uk

BMJ Case Reports

|July 11, 2012

Summary

A delayed reaction to piperacillin/tazobactam caused severe thrombocytopaenia in a sepsis patient. Intravenous immunoglobulin therapy was necessary to restore normal platelet counts.

Related Experiment Videos

Last Updated: May 20, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

Pharmacology
Hematology
Infectious Diseases

Background:

Sepsis is a life-threatening condition requiring prompt antibiotic treatment.
Pelvi-ureteric junction obstruction can lead to sepsis.
Piperacillin/tazobactam is a commonly used antibiotic for severe infections.

Observation:

A 48-year-old female patient presented with sepsis due to pelvi-ureteric junction obstruction.
She received an extended course of piperacillin/tazobactam.
Four days post-treatment, she developed severe thrombocytopaenia (low platelet count).

Findings:

The patient required intravenous immunoglobulin (IVIG) to normalize her platelet count.
No other causes for thrombocytopaenia were identified.
A delayed hypersensitivity reaction to piperacillin/tazobactam was suspected as the cause.

Implications:

This case highlights a rare delayed adverse reaction to piperacillin/tazobactam.
Awareness of this potential side effect is crucial for clinicians.
Further investigation into the mechanisms of delayed antibiotic-induced thrombocytopaenia may be warranted.