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Maternal vitamin A supplementation in relation to selected birth defects
M M Werler1, E J Lammer, L Rosenberg
1Stone Epidemiology Unit, School of Public Health, Boston University School of Medicine, Brookline, Massachusetts 02146.
Teratology
|November 1, 1990
Summary
Maternal vitamin A supplement use in early pregnancy may be linked to birth defects. Further research is needed due to tentative findings and lack of dose information.
Area of Science:
- Teratology
- Developmental Biology
- Public Health
Background:
- High doses of vitamin A are known teratogens in animals.
- Concerns about vitamin A teratogenicity in humans are heightened by isotretinoin's effects.
- Cranial neural crest cell activity is a potential mechanism for vitamin A-induced birth defects.