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Prevalence of chronic kidney disease in patients undergoing cardiac rhythm device removal
Arif Asif1, Roger Carrillo, Juan Domingo Garisto
1Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, Florida 33136, USA. aasif@med.miami.edu
Insights
Cardiac implantable electronic device (CIED) patients often have chronic kidney disease (CKD). One-third of patients needing CIED removal have advanced CKD, impacting dialysis access and infection risk.
Area of Science:
- Nephrology
- Cardiology
- Medical Devices
Background:
- Cardiac implantable electronic devices (CIEDs) can lead to central venous stenosis and infection.
- These complications are particularly concerning for patients with chronic kidney disease (CKD).
- CKD patients require functional central veins for dialysis access and have increased CIED infection risk.
Purpose of the Study:
- To investigate the prevalence and severity of chronic kidney disease (CKD) in patients with cardiac implantable electronic devices (CIEDs).
Main Methods:
- Retrospective analysis of 503 patients undergoing CIED removal between 2001 and 2011.
- Patients were categorized into CKD stages I-V using National Kidney Foundation-Dialysis Outcomes Quality Initiative guidelines.
Main Results:
- 90% of patients had CKD; 32.7% had advanced CKD (Stage III B, IV, or V).
- Patients undergoing CIED removal frequently have comorbidities like hypertension, diabetes, coronary artery disease, and congestive heart failure.
- A significant portion of CIED patients exhibit advanced renal failure.
Conclusions:
- One-third of patients requiring CIED removal present with advanced chronic kidney disease.
- This finding highlights the critical interplay between CIEDs, CKD, and potential complications like central venous stenosis and infection.
Abstract:
Cardiac implantable electronic device (CIED) leads can cause central venous stenosis (CVS). In addition, these devices can get infected. Both are critically important considerations in patients with chronic kidney disease (CKD) for at least two reasons: (i) central veins serve as the final pathway should these patients need an arteriovenous access to provide dialysis therapy; and (ii) the presence of renal failure increases the risk of CIED infection. In this analysis, we investigated the prevalence as well as the degree of chronic kidney disease in patients harboring a CIED. Patients undergoing CIED removal were evaluated from 2001 to 2011. The patients were categorized into CKD stage I-V based on National Kidney Foundation-Dialysis Outcomes Quality Initiative guidelines. A total of 503 patients underwent CIED removal. Demographic characteristics revealed that 30% had hypertension, 44% were diabetics, 77% had coronary artery disease, and 84% suffered from congestive heart failure. Ninety percent (452/503) of the patients had CKD (stage I = I9 [4.2%], stage II = 189 [41.8%], stage III A = 96 [21.2%], stage III B = 59 [13.0%], stage IV = 45 [9.9%], and stage V = 44 [9.7%]). Overall, 148 (32.7%) patients (stage III B, stage IV, and stage V) of 452 had advanced renal failure. The results of this study reveal that one-third of CIED patients undergoing device removal have advanced chronic kidney disease.
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