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Related Experiment Video

Updated: May 20, 2026

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills

Published on: September 17, 2019

[Application of log-linear model in the case-parent triad study].

Ming Zhu¹, Shao-fa Nie, Wei-rong Yan

¹Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi

|July 12, 2012

Summary

Mothers with two copies of the MTHFR C677T variant allele showed a reduced risk of cleft lip and palate (CL/P) in offspring. Log-linear models effectively analyzed genetic effects in case-parent triad studies.

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Area of Science:

Genetics
Epidemiology
Statistical Modeling

Context:

Cleft lip with or without cleft palate (CL/P) is a common birth defect.
The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is studied for its role in CL/P.
Case-parent triad studies are valuable for dissecting genetic and environmental influences.

Purpose:

To introduce and apply a log-linear model for case-parent triad studies.
To investigate maternal and fetal effects, and their interaction, on CL/P risk.
To analyze the association between MTHFR C677T genotype and CL/P.

Summary:

Log-linear models were used to analyze MTHFR C677T associations with CL/P in 145 case-parent triads.
Maternal carriage of two MTHFR C677T variant alleles significantly reduced CL/P risk (S2=0.43, 95% CI: 0.19-0.95).
No significant fetal genotype or maternal-fetal interaction effects on CL/P were detected.

Impact:

Log-linear models provide a robust method for estimating maternal and fetal effects in genetic studies.
This approach is beneficial for complex diseases, including pregnancy complications and fetal-origin diseases.
Findings highlight a protective maternal effect of the MTHFR C677T variant against CL/P.