Related Experiment Video
Updated: May 20, 2026
Production of Modified Autologous Conditioned Serum and Ex Vivo Assessment of Its Healing Potential in Murine Corneal Epithelium
Published on: March 24, 2023
Management of bullous keratopathy-related ulcer with autologous serum
Asimina Mataftsi1, Areti Bourtoulamaiou, Konstantinos Anastasilakis
1IInd Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece. mataftsi@doctors.org.uk
Purpose:
The aim of this study was to report the use of autologous serum eyedrops (ASEs) for resolution of a corneal ulcer secondary to bullous keratopathy.
Methods:
This is a case report.
Results:
A 66-year-old patient presented with an infected ulcer and hypopyon while using a bandage contact lens for bullous keratopathy. Staphylococcus warneri infection was treated with systemic and topical antibiotics, and ASEs were subsequently administered to enhance reepithelialization and to avoid the need for a bandage contact lens. The ASE treatment led to closure of the epithelium layer within 3 weeks, and it was subsequently tapered over the next 3 months. The clinical picture remained stable subjectively and objectively during the 7 months of follow-up.
Discussion:
To the best of our knowledge, this is the first report of successful use of ASEs in treating and preventing recurrence of ulcers in the context of bullous keratopathy.
