Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions01:15

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure (CHF).

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Impact of different blood pressure targets on cerebral hemodynamics in septic shock: A prospective pilot study protocol-SEPSIS-BRAIN.

PloS one·2026
Same author

Harmonizing Continuous Hemodynamic Assessment in Acute Stroke: A Practical Approach.

Stroke·2026
Same author

A response to the Comment on "The effect of end-tidal carbon dioxide levels on dynamic cerebral autoregulation and clinical outcome in acute ischemic stroke: an INFOMATAS study".

Journal of the neurological sciences·2026
Same author

Feasibility of integrated transcranial doppler ultrasound-near-infrared spectroscopy to measure cerebral haemodynamics in dementia, delirium, and depression (the VESPAR Project): A pilot study.

Journal of neuroscience methods·2026
Same author

Simultaneous macrovasculature and microvasculature cerebral autoregulation derived from the transfer function analysis of integrated cerebral haemodynamic data in older adults.

Physiological measurement·2026
Same author

The effect of end-tidal carbon dioxide levels on dynamic cerebral autoregulation and clinical outcome in acute ischemic stroke: An INFOMATAS study.

Journal of the neurological sciences·2026

Related Experiment Video

Updated: May 20, 2026

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
10:05

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

Comparative study of Finapres devices.

Kong Yien Chin1, Ronney B Panerai

  • 1Department of Medical Physics, University Hospitals of Leicester, NHS Trust, Leicester, UK. kong.chin@uhl-tr.nhs.uk

Blood Pressure Monitoring
|July 12, 2012
PubMed
Summary
This summary is machine-generated.

Two Finapres devices showed significant resting blood pressure (BP) differences but agreed well on dynamic indices. Their adequate frequency response supports waveform analysis in continuous noninvasive BP monitoring.

More Related Videos

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology
10:41

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology

Published on: September 13, 2022

Related Experiment Videos

Last Updated: May 20, 2026

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
10:05

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology
10:41

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology

Published on: September 13, 2022

Area of Science:

  • Cardiovascular physiology
  • Biomedical engineering
  • Noninvasive monitoring technologies

Background:

  • Arterial volume clamping devices like Finapres are standard for continuous noninvasive blood pressure (BP) monitoring.
  • Validation typically uses invasive radial artery BP, but device variability is a concern.
  • This study assessed agreement between two Finapres devices under various conditions.

Purpose of the Study:

  • To evaluate the consistency of blood pressure (BP) readings between two Finapres devices.
  • To determine if simultaneous use of two Finapres devices yields significant differences in measurements.
  • To assess the agreement of dynamic BP indices derived from two Finapres devices.

Main Methods:

  • Two identical Finapres devices were used on 11 healthy individuals.
  • BP was measured simultaneously on different finger/hand combinations.
  • Agreement was assessed at rest (systolic, mean, diastolic BP, drift, bandwidth, coherence) and during the Valsalva maneuver.

Main Results:

  • Significant differences were observed between the two Finapres devices for resting systolic, mean, and diastolic BP.
  • No significant differences were found for drift, bandwidth, or response to the Valsalva maneuver.
  • Spectral and coherence analysis indicated a linear frequency response up to approximately 13 Hz.

Conclusions:

  • While resting BP measurements may differ between Finapres devices, dynamic indices show excellent agreement.
  • The devices possess adequate bandwidth for accurate BP waveform registration, supporting waveform-dependent analyses.
  • Further research is needed in patient populations, especially those with circulatory disorders.