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Updated: May 20, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
[A clinical analysis of dermatomyositis with interstitial lung disease in 20 patients]
Hong Li1, Qing Lin, Hong-mei Jiao
1Department of Geriatric, Peking University First Hospital, Beijing 100034, China. lih7510@163.com
Objective:
To investigate the clinical features of the patients with dermatomyositis (DM) complicated with interstitial lung disease (ILD).
Methods:
The clinical manifestations and the laboratory data of the 20 patients with DM complicated with ILD were retrospectively analyzed.
Results:
Among 169 DM patients, 20(11.8%) were founded with ILD and 4 had no complaint of respiratory system. The ratio of male to female was 1:2.33. The level of serum creatine kinase (CK) was elevated in 11 cases. Anti-Jo-1 antibody was positive in 4 cases. Bilateral infiltrates including ground-glass attenuation, interlobular septal thickening and reticular opacities were found by chest high resolution computed tomography. The impairment of lung function was manifested as the decreased diffusion capacity for carbon monoxide of the lung (D(L)CO) and restricted ventilatory function abnormalities. Fifteen cases showed hypoxemia or respiratory failure by arterial blood gas analysis. All patients were treated with glucocorticoid and/or immunosuppressive agents. Totally, 14 patients had improved, while 2 patients with no improvement and 4 patients died with a mortality of 20%.
Conclusions:
DM complicated with ILD which is easily missed has a high morbidity and mortality. The understanding of DM complicated with ILD should be enhanced, thus early diagnosis and intervention could be performed for better prognosis.
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