Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Angiotensin II blockers improves cardiac coronary flow under hemodynamic pressure overload.

Hypertension research : official journal of the Japanese Society of Hypertension·2025
Same author

Circular RNA circIGF1R controls cardiac fibroblast proliferation through regulation of carbohydrate metabolism.

Scientific reports·2025
Same author

How to facilitate seamless translation from basic concepts to new heart failure drugs. A scientific statement of the Heart Failure Association of the ESC.

European journal of heart failure·2025
Same author

Exploring hiPSC-CM replacement therapy in ischemic hearts.

Basic research in cardiology·2025
Same author

Living myocardial slices: walking the path towards standardization.

Cardiovascular research·2025
Same author

Pathophysiology and clinical use of agents with vasodilator properties in acute heart failure. A scientific statement of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).

European journal of heart failure·2025
Same journal

Anti-TFPI Single-Domain Antibodies: Novel Rebalancing Therapies for Hemophilia and Other Rare Bleeding Disorders.

Thrombosis and haemostasis·2026
Same journal

The Interaction of Fibrin with Endothelial Cell Receptor N-Cadherin Promotes Fibrin-Dependent Angiogenesis.

Thrombosis and haemostasis·2026
Same journal

Antiphospholipid Antibodies and Atrial Fibrillation: Clinical Implications and the TaPL AF Study Design.

Thrombosis and haemostasis·2026
Same journal

Prasugrel vs. Ticagrelor: Can TUXEDO-2 Settle the Debate?

Thrombosis and haemostasis·2026
Same journal

Methylglyoxal Promotes RBC-Driven Procoagulant Activity and Venous Thrombosis under Diabetes-Relevant Conditions.

Thrombosis and haemostasis·2026
Same journal

Management of Inferior Vena Cava Thrombosis: Guidance from the Italian Society for the Study of Haemostasis and Thrombosis.

Thrombosis and haemostasis·2026
See all related articles

Related Experiment Video

Updated: May 20, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

MicroRNAs in platelet biogenesis and function.

Seema Dangwal1, Thomas Thum

  • 1Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany.

Thrombosis and Haemostasis
|July 12, 2012
PubMed
Summary
This summary is machine-generated.

Platelets utilize microRNAs (miRNAs) for post-transcriptional gene regulation, influencing hemostasis and vascular disorders. This review highlights key miRNAs in platelet biology and function.

More Related Videos

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Proplatelet Formation Dynamics of Mouse Fresh Bone Marrow Explants
05:58

Proplatelet Formation Dynamics of Mouse Fresh Bone Marrow Explants

Published on: May 20, 2021

Related Experiment Videos

Last Updated: May 20, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Proplatelet Formation Dynamics of Mouse Fresh Bone Marrow Explants
05:58

Proplatelet Formation Dynamics of Mouse Fresh Bone Marrow Explants

Published on: May 20, 2021

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Hematology

Background:

  • Platelets are crucial for primary hemostasis and implicated in thrombotic disorders like stroke.
  • Despite lacking nuclei, platelets contain various RNAs, including messenger RNAs and small non-coding RNAs from megakaryocytes.
  • Platelets possess translational machinery, enabling protein synthesis and post-transcriptional gene regulation.

Purpose of the Study:

  • To review recently identified megakaryocytic/platelet microRNAs (miRNAs).
  • To discuss the role of these miRNAs in platelet biogenesis and function.
  • To underscore the significance of miRNAs in maintaining hemostasis.

Main Methods:

  • Literature review of recent findings on megakaryocytic/platelet miRNAs.
  • Analysis of miRNA expression patterns during platelet genesis and activation.
  • Discussion of miRNA-mediated post-transcriptional gene regulation in platelets.

Main Results:

  • Platelets contain diverse RNA types, including miRNAs, inherited from megakaryocytes.
  • MicroRNAs regulate protein expression by targeting messenger RNAs.
  • Altered miRNA expression is observed during platelet biogenesis and activation.

Conclusions:

  • MicroRNAs play a significant role in platelet biology, affecting biogenesis and function.
  • Understanding platelet miRNAs is essential for comprehending hemostasis and thrombotic disorders.
  • Further research into specific miRNAs can reveal novel therapeutic targets.