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Updated: May 20, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
Published on: July 28, 2020
[Soft tissue sarcoma : resection and plastic reconstruction]
H U Steinau1, L Steinsträsser, J Hauser
1Klinik für Plastische Chirurgie und Schwerbrandverletzte, Operatives Referenzzentrum für Weichgewebssarkome, BG Universitätsklinik Bergmannsheil der RUB, Bürkle de la Camp Platz 1, 44799, Bochum, Deutschland. hans-ulrich.steinau@bergmannsheil.de
Abstract:
Adequate surgical removal of soft tissue sarcomas of the trunk and extremities employing safety margins of 1-2 cm is the accepted basis of multidisciplinary treatment. In cases of high risk tumors (grades G2/G3) the tumor board decision should include radiochemotherapy under study conditions. Difficult peripheral locations or perioperative complications require additional techniques, such as hyperthermic perfusion with tumor necrosis factor alpha or the complete spectrum of reconstructive plastic procedures. Patients with soft tissue sarcoma of the trunk or of the extremities should always be referred to high volume centers.