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Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...

Irritable Bowel Syndrome

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DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...

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The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

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Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:

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Chronic Salmonella Infection Induced Intestinal Fibrosis

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Brain-Gut Interactions in IBS.

Jakub Fichna¹, Martin A Storr

¹Department of Biomolecular Chemistry, Faculty of Medicine, Medical University of Lodz Lodz, Poland.

Frontiers in Pharmacology

|July 12, 2012

Summary

Irritable bowel syndrome (IBS) is a common disorder lacking clear biomarkers. This review explores the brain-gut axis (BGA) involvement in IBS and potential new therapies.

Area of Science:

Gastroenterology
Neuroscience
Psychiatry

Background:

Irritable bowel syndrome (IBS) affects 10-20% of the population.
IBS pathophysiology is poorly understood due to absent biomarkers and clear abnormalities.
Contributing factors include physical stressors, psychological elements, and environmental influences.

Purpose of the Study:

To review current knowledge on the brain-gut axis (BGA) in IBS.
To discuss potential future therapeutic strategies for IBS.

Main Methods:

Literature review of studies investigating the BGA in IBS.
Analysis of potential mechanisms linking the BGA to IBS symptoms.

Main Results:

The brain-gut axis (BGA) is implicated in IBS development and symptoms.

Keywords:

autonomic nervous system brain-gut axis hypothalamo-pituitary-adrenal axis irritable bowel syndrome pathophysiology

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Various stressors and psychological factors may influence the BGA in IBS.

Conclusions:

The BGA plays a significant role in IBS.
Further research into the BGA may lead to novel IBS therapies.