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Related Experiment Video

Updated: May 20, 2026

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering
08:04

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

Published on: April 25, 2013

Tissue bioengineering in orthopedics.

Philippe Hernigou1, Yasuhiro Homma

  • 1Hospital Henri Mondor, University Paris East, Paris, France.

Clinical Cases in Mineral and Bone Metabolism : the Official Journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases
|July 12, 2012
PubMed
Summary

Orthopedic tissue engineering, utilizing cells for bone repair, has evolved significantly since the 17th century. Modern advances in cell biology, growth factors, and biomaterials are revolutionizing bone grafting and regeneration for orthopedic surgeons.

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Area of Science:

  • Orthopedic Surgery
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • The historical use of cells in orthopedic tissue engineering dates back over 300 years.
  • Early pioneers like Job-Van Meek'ren, Ollier, Goujon, Macewen, Albee, and Phemister established foundational bone grafting techniques.
  • Traditional autografting methods have seen limited changes until recent advancements.

Purpose of the Study:

  • To review the historical progression of cell-based orthopedic tissue engineering.
  • To highlight the impact of recent scientific and technological breakthroughs on bone grafting and regeneration.
  • To emphasize the central role of cell-matrix composites in current tissue engineering.

Main Methods:

  • Historical literature review of seminal works in bone grafting and tissue engineering.
Keywords:
bonestem cellstissue engineering

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  • Analysis of the evolution of techniques and understanding of osteogenic principles.
  • Examination of the integration of cell biology, growth factors, and biomaterials.

    • Main Results:

    • Bone grafting techniques have a long history, with early work focusing on periosteum and bone marrow.
    • Contemporary advances leverage cell biology, peptide growth factors, and specialized implantable materials.
    • Tissue engineering has spurred significant innovation in orthopedic bone healing.

    Conclusions:

    • Cell-matrix composites are fundamental to modern orthopedic tissue engineering.
    • The field is rapidly expanding the options available for bone healing and regeneration.
    • These advancements offer new solutions for orthopedic surgeons across various clinical settings.