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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Epidemiologic overview of malignant lymphoma
1Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
The Korean Journal of Hematology
|July 12, 2012
Summary
Malignant lymphoma incidence is rising globally, with geographic variations in subtypes. Factors like aging populations and environmental exposures contribute to this complex cancer epidemic.
Area of Science:
- Oncology
- Epidemiology
Background:
- Malignant lymphoma incidence is increasing globally, particularly in developing nations, though stabilization is noted in developed countries.
- The global rise in lymphoma incidence, estimated at 3-4% annually over four decades, is poorly understood but linked to diagnostics, aging populations, and lifestyle factors.
- Geographic variations in lymphoma subtypes exist, with T/natural killer (NK) cell lymphomas and mucosa-associated lymphoid tissue (MALT) lymphomas more prevalent in Asia compared to Western countries.
Purpose of the Study:
- To review the geographic distribution and etiologies of malignant lymphoma.
- To discuss trends in malignant lymphoma incidence and subtype prevalence worldwide.
- To highlight ethnic and environmental factors influencing the diversity of malignant lymphoma subtypes.
Main Methods:
- Literature review of malignant lymphoma incidence, distribution, and etiology.
- Analysis of global and regional trends in lymphoma epidemiology.
- Comparison of lymphoma subtype prevalence between Western countries and Asia.
Main Results:
- Malignant lymphoma is more common in developed countries, with East Asia showing lower incidence rates.
- T/NK-cell lymphomas and MALT lymphomas are relatively more common in Asia, while follicular lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma are less common.
- Certain Epstein-Barr virus-associated T/NK-cell lymphomas are predominantly found in Asian populations.
Conclusions:
- Malignant lymphoma exhibits significant geographic variation in incidence and subtype distribution.
- Ethnic and environmental factors are crucial in understanding the diversity of malignant lymphoma.
- Further research is needed to elucidate the causes of the global lymphoma epidemic.
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