Related Experiment Video
Updated: May 20, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
Circannual temperature-related variation in hemoglobin A1c is unlikely to affect its use as a diagnostic test for
Li Xue1, Hongyan Liang, Xiaofeng Jiang
1Department of Clinical Biochemistry Laboratory, The 4th Affiliated Hospital of Harbin Medical University, Harbin, China.
Background:
To evaluate the relationship between temperature and hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG) levels in Harbin of China and analyze whether these would affect diagnosis and control of diabetes.
Methods:
Two groups were investigated: 1. Routine patients come from outpatients, 2. Research subjects including 224 healthy volunteers and 391 diabetic patients, who had 5 blood specimens collected between February and June 2010. Fasting plasma glucose and hemoglobin A1c were detected.
Results:
In non-diabetic patients, mean HbA1c concentrations for all temperature categories were not significantly different, but mean FPG level was higher at cooler temperatures (p < 0.05). In the diabetic group, mean HbA1c concentrations were higher at cool temperatures than at very cold temperatures (p < 0.05), but mean FPG level was higher at cold temperature than at other temperature categories (p < 0.05). Both the within- and the between-subject coefficients of variation (CVs) for HbA1c were smaller than for FPG.
Conclusions:
During the year of this study, there were substantial temperature fluctuations but HbA1c concentration was more stable than FPG in non-diabetic individuals. It is therefore unlikely that temperature-related variation in HbA1c could affect the use of HbA1c as a diagnostic test for type 2 diabetes, but could affect the use of HbA1c as a glycemia control test for diabetes.
More Related Videos
Related Concept Videos
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Diabetes Mellitus: Type 2 and Gestational
Hyperglycemia
Diabetes: Symptoms, Diagnosis, and Complications
Temperature Measurement Sites
Oral: When assessing oral temperature, the thermometer tip should be placed under the tongue in the posterior sublingual pocket. It offers accurate readings and can be...
Hypoglycemia

