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Biomarker Identification for Gender Specificity of Alzheimer's Disease Based on the Glial Transcriptome Profiles

Biomarker Identification for Gender Specificity of Alzheimer's Disease Based on the Glial Transcriptome Profiles

Published on: May 20, 2024

Accelerated aging-related transcriptome changes in the female prefrontal cortex.

Yuan Yuan¹, Yi-Ping Phoebe Chen, Jerome Boyd-Kirkup

¹Key Laboratory for Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China.

|July 13, 2012

Summary

This summary is machine-generated.

Women experience faster brain aging, with earlier cognitive decline and increased Alzheimer's disease (AD) risk. This study reveals sex-based differences in brain gene expression timing, linking faster female brain aging to AD prevalence.

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Biomarker Identification for Gender Specificity of Alzheimer's Disease Based on the Glial Transcriptome Profiles

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Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

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Published on: February 24, 2023

Area of Science:

Neuroscience
Genomics
Aging Research

Background:

Female life expectancy exceeds males, yet women exhibit faster age-related cognitive decline and higher Alzheimer's disease (AD) prevalence.
Contradictory trends in longevity and cognitive aging necessitate investigation into molecular underpinnings.

Purpose of the Study:

To investigate sex-specific differences in age-related gene expression patterns across four brain regions.
To identify molecular mechanisms contributing to accelerated brain aging in females and its potential link to Alzheimer's disease.

Main Methods:

Analysis of age-related gene expression changes in adult male and female brain tissues.
Focus on the superior frontal gyrus (SFG) to examine sexual heterochrony in gene expression timing.

Main Results:

Significant sex differences in the timing of age-related gene expression changes were observed, particularly in the SFG.
Females exhibited accelerated age-related expression changes, including reduced energy production, impaired neural function, and heightened immune response.
Accelerated female SFG transcriptome changes correlated with Alzheimer's disease (AD) expression profiles and frontal cortex stress responses.

Conclusions:

Sexual heterochrony in brain aging, with faster progression in females, is identified as a key factor.
Accelerated aging in the female SFG transcriptome may mediate the link between higher stress sensitivity in women and increased Alzheimer's disease (AD) risk.