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Determination of haloperidol and hydroxy haloperidol in human plasma by high performance liquid chromatography
J Pommery1, O Foulon, G Morineau
1Laboratoire de Toxicologie, Faculté de Pharmacie, Laguesse, Lille.
Annales De Biologie Clinique
|January 1, 1990
Abstract:
A method has been developed for the separation and measurement of haloperidol and hydroxy haloperidol in human plasma through high performance liquid chromatography. The method uses chlorohaloperidol as an internal standard and provides a limit of detection of about 0.7 nmol/l for haloperidol and 0.67 nmol/l for hydroxy haloperidol. HPLC and RIA radioimmunoassay methods are compared.