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Urea cycle disorder--argininosuccinic lyase deficiency
Neeta Mehta1, Pia Chatterjee Kirk, Ray Holder
1Department of Advanced Dentistry, School of Dentistry, University of Mississippi, Jackson, Mississippi, USA. nmehta@umc.edu
Abstract:
An increased level of ammonia in the bloodstream, or hyperammonemia, is a symptom associated with metabolic disorders referred to as inborn errors of metabolism. Urea cycle disorder is a congenital abnormality or absence of one of the six enzymes involved in the elimination of ammonia. Administration of certain medications, high protein diet, excessive exercise, surgical procedures, or trauma can precipitate symptoms of mental confusion, seizure-like activity, and ataxia. This paper reviews the literature with insight into current treatment and management options of the disorder and modification of treatment for the dental patient.
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