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In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis
Published on: June 8, 2022
[Intestinal invagination: clinico-therapeutic study in a pediatric emergency service]
J R Lasarte Iradi1, A Cuadrado Canales, M A Lizarraga Azparren
1Departamento de Pediatría, Hospital de Cruces, Baracaldo, Vizcaya.
Insights
Intussusception in infants can present atypically with neurological signs, prompting earlier consultation. Early diagnosis and treatment, often with barium enema hydrostatic reduction, are crucial, with surgery needed in only 22% of cases.
Area of Science:
- Pediatrics
- Gastroenterology
- Surgical Innovation
Context:
- Intussusception is a common surgical emergency in infants.
- Atypical presentations can delay diagnosis and treatment.
- This study reviews a single-year cohort of infant intussusception cases.
Purpose:
- To highlight the significance of atypical neurological presentations in infant intussusception.
- To evaluate the association between clinical signs and the need for surgery.
- To assess the efficacy of barium enema hydrostatic reduction as a primary intervention.
Summary:
- Reviewed 64 infants with intussusception, noting six atypical cases presenting with neurological signs who sought earlier medical attention.
- Found a significant association between bloody stools and the requirement for surgical intervention (p < 0.05).
- Barium enema hydrostatic reduction was employed as the primary diagnostic and therapeutic modality, with surgery ultimately required in only 22% of patients.
Impact:
- Increased awareness of subtle neurological signs can lead to earlier diagnosis of intussusception in infants.
- Barium enema hydrostatic reduction is an effective primary treatment, minimizing the need for surgery.
- This approach improves outcomes for infants with intussusception.
Abstract:
Sixty four infants with intussusception diagnosed in one year period are reviewed. The atypical form of presentation with only neurological signs, observed in six patients, is emphasized. These children consulted at an earlier time than those with the classic clinical picture. So that, a high degree of awareness is necessary. There was a significant association between bloody stools and need of surgery (p less than 0.05). We think that barium enema hydrostatic reduction is the primary form of diagnostic and treatment. Only 14 patients (22%) eventually required surgery.
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