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Exocytosis

Exocytosis

Exocytosis is used to release material from cells. Like other bulk transport mechanisms, exocytosis requires energy.

Exocytosis

Exocytosis

Exocytosis is a process that releases molecules outside the cell. Like other bulk transport mechanisms, exocytosis requires energy.
Exocytosis is the opposite of endocytosis, which brings molecules inside the cell. Sometimes, the released materials are signaling molecules. For example, neurons typically use exocytosis to release neurotransmitters. Cells also use exocytosis to insert proteins such as ion channels into their cell membranes, secrete proteins for use in the extracellular matrix, or...

Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis

Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis

Vesicular transport is a cellular process that encompasses the engulfment of particles or dissolved substances by cells. It involves endocytosis, transcytosis, and exocytosis.
Endocytosis is a cellular mechanism that involves the inward folding of the cell membrane to create vesicles that capture and transport large drug molecules. This process comprises two distinct methods: pinocytosis (often referred to as "cell drinking") and phagocytosis (often referred to as "cell eating"). Pinocytosis is...

Overview of Secretory Vesicles

Overview of Secretory Vesicles

Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...

Intralumenal Vesicles and Multivesicular Bodies

Intralumenal Vesicles and Multivesicular Bodies

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Fusion of Secretory Vesicles with the Plasma Membrane

Fusion of Secretory Vesicles with the Plasma Membrane

Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...

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Related Experiment Video

Updated: May 20, 2026

Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells

Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells

Published on: September 16, 2020

Regulated exocytosis per partes.

Jens R Coorssen, Robert Zorec

|July 13, 2012

Summary

This summary is machine-generated.

Regulated exocytosis is a vital cellular process involving vesicle fusion with the plasma membrane. Understanding its molecular mechanisms is key to physiological insights and disease therapies.

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Last Updated: May 20, 2026

Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells

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Imaging FITC-dextran as a Reporter for Regulated Exocytosis

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Automated Detection and Analysis of Exocytosis

Automated Detection and Analysis of Exocytosis

Published on: September 11, 2021

Area of Science:

Cell Biology
Molecular Biology

Background:

Regulated exocytosis is a fundamental process in eukaryotic cells involving vesicle fusion and content release.
This process includes vesicle delivery, membrane merger, pore formation, and membrane retrieval via endocytosis.
Transient fusion pore opening, or kiss-and-run exocytosis, is also a recognized mechanism.

Discussion:

Despite extensive research, the precise molecular mechanisms of regulated exocytosis remain incompletely understood.
Variations in the speed of exocytosis stages across cell types, such as neurons, present experimental challenges.
A comprehensive physiological insight into the coupled stages of exocytosis is still lacking.

Key Insights:

The Special Issue covers rapid regulated exocytosis, calcium homeostasis, molecular mechanisms, and cell models.
Investigating exocytosis at the molecular level is crucial for in vitro reconstruction.
Understanding exocytosis can identify therapeutic targets for various diseases.

Outlook:

Further research is needed to fully elucidate the molecular underpinnings of regulated exocytosis.
Developing detailed models of exocytosis will aid in understanding its physiological roles.
Identifying therapeutic targets related to exocytosis dysfunction holds promise for treating diseases.