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Antiplatelet therapy as a risk factor for microbleeds in intracerebral hemorrhage patients: analysis using specific

Hiromitsu Naka1, Eiichi Nomura, Jyuri Kitamura

  • 1Department of Neurology, Hiroshima Prefectural Hospital, Hiroshima, Japan. hiromitsunaka@yahoo.co.jp

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|July 13, 2012
PubMed
Abstract

Insights

Antiplatelet use, particularly aspirin, is linked to brain microbleeds in patients with intracerebral hemorrhage. Careful consideration is needed for microbleed-positive individuals to prevent hemorrhages.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Neuroimaging

Background:

  • Brain microbleeds are a known risk factor for antiplatelet-associated intracerebral hemorrhage.
  • Limited data exist on specific antiplatelet agents and their association with brain microbleeds.

Purpose of the Study:

  • To investigate the association between specific antiplatelet agents and brain microbleeds in acute stroke patients.
  • To inform the selection of antiplatelet therapy in patients with existing microbleeds.

Main Methods:

  • Evaluation of 1914 consecutive acute stroke patients (412 with intracerebral hemorrhage, 1502 with ischemic stroke).
  • Analysis of associations between microbleeds and use of specific antiplatelets: aspirin, clopidogrel, cilostazol, and ticlopidine.

Main Results:

  • Antiplatelet use was significantly associated with microbleeds in intracerebral hemorrhage patients (OR 2.418), but not ischemic stroke patients.
  • Aspirin use showed a significant association with microbleeds in intracerebral hemorrhage patients (OR 2.160).
  • Deep microbleeds, not lobar, were associated with antiplatelet use in intracerebral hemorrhage patients.

Conclusions:

  • Patients with microbleeds require careful monitoring when using aspirin to mitigate hemorrhage risk.
  • Prospective studies are essential to validate these findings and guide clinical practice.
Keywords:
Antiplatelet agentsintracerebral hemorrhagemicrobleeds

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