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Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury
Published on: September 7, 2018
Lyophilized aspirin with trehalose may decrease the incidence of gastric injuries in healthy dogs
Lee-Shuan Lin1, Yuko Kayasuga, Nobuyuki Shimohata
1Department of Veterinary Surgery, Graduate School of Agriculture and Life Science, The University of Tokyo, Tokyo, Japan.
The Journal of Veterinary Medical Science
|July 13, 2012
Summary
Lyophilized aspirin/trehalose significantly reduced gastric ulceration in dogs compared to aspirin alone. This novel formulation may offer a safer way to use aspirin, preserving therapeutic levels while minimizing gastrointestinal damage.
Area of Science:
- Pharmacology
- Gastroenterology
- Biochemistry
Background:
- Aspirin is widely used but can cause gastric damage (gastropathy).
- Trehalose exhibits anti-inflammatory and cell-protective properties.
- Novel formulations are needed to mitigate aspirin-induced gastrointestinal side effects.
Purpose of the Study:
- To investigate if lyophilized aspirin/trehalose reduces aspirin-induced gastropathy in a canine model.
- To compare the severity of gastric lesions between aspirin and lyophilized aspirin/trehalose treatments.
- To assess plasma aspirin concentrations to ensure therapeutic efficacy.
Main Methods:
- A canine study involving three groups: aspirin, lyophilized aspirin/trehalose, and control.
- Gastric lesions were evaluated using gastroscopy and the modified Lanza scale.
- Plasma aspirin concentrations were measured via high-performance liquid chromatography.
Main Results:
- Lyophilized aspirin/trehalose induced significantly less gastric ulceration compared to aspirin alone.
- Therapeutic plasma concentrations of aspirin were maintained with both aspirin and lyophilized aspirin/trehalose formulations.
- The control group showed no significant gastric lesions.
Conclusions:
- Lyophilized aspirin/trehalose demonstrates a protective effect against aspirin-induced gastropathy.
- This formulation may represent a viable strategy to reduce gastrointestinal side effects of aspirin therapy.
- Further research into trehalose-based drug delivery systems is warranted.
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