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Updated: May 20, 2026

Detection of Infectious Virus from Field-collected Mosquitoes by Vero Cell Culture Assay
Published on: June 9, 2011
West nile virus disease and other arboviral diseases - United States, 2011
Abstract:
Arthropodborne viruses (arboviruses) are transmitted to humans primarily through the bites of infected mosquitoes and ticks. Symptomatic infections most often manifest as a systemic febrile illness and, less commonly, as neuroinvasive disease (e.g., meningitis, encephalitis, or acute flaccid paralysis). West Nile virus (WNV) is the leading cause of domestically acquired arboviral disease in the United States. However, several other arboviruses also cause seasonal outbreaks and sporadic cases. In 2011, CDC received reports of 871 cases of nationally notifiable arboviral diseases (excluding dengue); etiological agents included WNV (712 cases), La Crosse virus (LACV) (130), Powassan virus (POWV) (16), St. Louis encephalitis virus (SLEV) (six), Eastern equine encephalitis virus (EEEV) (four), and Jamestown Canyon virus (JCV) (three). Of these, 624 (72%) were classified as neuroinvasive disease, for a national incidence of 0.20 per 100,000 population. WNV and other arboviruses continue to cause focal outbreaks and severe illness in substantial numbers of persons in the United States.
Insights
Arthropodborne viruses (arboviruses) transmitted by mosquitoes and ticks cause serious neuroinvasive diseases in the US. West Nile virus (WNV) is the most common, but other arboviruses also pose significant public health risks.
Area of Science:
- Medical Entomology
- Infectious Diseases
- Neurovirology
Background:
- Arthropodborne viruses (arboviruses) are transmitted by infected mosquitoes and ticks.
- Infections can cause systemic febrile illness or severe neuroinvasive disease, including meningitis and encephalitis.
- West Nile virus (WNV) is the primary cause of arboviral disease acquired domestically in the United States.
Purpose of the Study:
- To summarize the national surveillance data for arboviral diseases in the United States for 2011.
- To highlight the incidence and types of arboviruses causing nationally notifiable diseases.
- To emphasize the significant proportion of neuroinvasive cases attributed to WNV and other arboviruses.
Main Methods:
- Analysis of nationally notifiable arboviral disease case reports submitted to the CDC in 2011.
- Categorization of etiological agents and classification of disease manifestation (neuroinvasive vs. non-neuroinvasive).
- Calculation of national incidence rates for arboviral diseases.
Main Results:
- In 2011, 871 cases of nationally notifiable arboviral diseases (excluding dengue) were reported.
- West Nile virus (WNV) accounted for the majority of cases (712), followed by La Crosse virus (LACV) (130).
- A significant majority (72%) of reported cases were classified as neuroinvasive disease, with a national incidence of 0.20 per 100,000 population.
Conclusions:
- Arboviruses, particularly WNV, continue to cause significant public health burdens in the United States.
- Neuroinvasive arboviral diseases represent a substantial proportion of reported cases.
- Ongoing surveillance and awareness are crucial for managing arboviral disease outbreaks.
Related Concept Videos
Arboviral Encephalitis
Encephalitis l: Introduction
Investigation of Disease Outbreaks
Infectious Diseases and Their Occurrence
Principles of Disease Surveillance
Encephalitis ll: Pathophysiology

