Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peptidoglycan Synthesis01:28

Peptidoglycan Synthesis

Structure of PeptidoglycanPeptidoglycan is a vital structural component of the bacterial cell wall, providing mechanical strength and shape to the cell. It consists of repeating units of two sugars—N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)—linked by β-1,4 glycosidic bonds. These sugar chains are cross-linked by short peptide chains, forming a mesh-like polymer that surrounds the bacterial plasma membrane.Cytoplasmic Phase – Precursor SynthesisPeptidoglycan biosynthesis begins in...
Proteoglycans01:05

Proteoglycans

Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
Protein Glycosylation01:25

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polyelectrolyte Copolymer Nanoreactors: From Colloidal Assembly to Photoredox Activity in Water.

ACS applied materials & interfaces·2026
Same author

Nanocrystalline Ordered Mesoporous Co(OH)<sub>2</sub> and Co<sub>3</sub>O<sub>4</sub> Thin Films: Oxygen Evolution Reaction Activity from a Structural Properties Perspective.

Small science·2026
Same author

Catechol-Containing Poly(2-isopropyl-2-oxazoline): Synthesis and Thermoresponsive Behavior in Aqueous Salt Solutions.

Macromolecular rapid communications·2025
Same author

Diblock Copolypeptoid Micelles as Platform for Aqueous Photoredox Cyanation of Arenes.

Journal of the American Chemical Society·2025
Same author

Solution Behavior of Glyco-Copoly(l-Glutamic Acid)s in Dilute Saline Solution.

Biomacromolecules·2024
Same author

Ring-Opening Terpolymerisation of Elemental Sulfur Waste with Propylene Oxide and Carbon Disulfide via Lithium Catalysis.

Angewandte Chemie (International ed. in English)·2024

Related Experiment Video

Updated: May 20, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

A versatile polypeptoid platform based on N-allyl glycine.

Joshua W Robinson1, Helmut Schlaad

  • 1Max Planck Institute of Colloids and Interfaces, Department of Colloid Chemistry, Research Campus Golm, 14424 Potsdam, Germany.

Chemical Communications (Cambridge, England)
|July 13, 2012
PubMed
Summary
This summary is machine-generated.

Researchers synthesized N-Allyl glycine N-carboxyanhydride (NCA) and polymerized it to create well-defined polypeptoids. The resulting poly(N-allyl glycine) showed stimuli-responsive behavior and was easily modified using thiol-ene chemistry.

More Related Videos

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Related Experiment Videos

Last Updated: May 20, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Area of Science:

  • Polymer Chemistry
  • Organic Synthesis
  • Materials Science

Background:

  • N-carboxyanhydrides (NCAs) are versatile monomers for synthesizing polypeptides.
  • Developing well-defined polymers with tunable properties is crucial for advanced materials.
  • Stimuli-responsive polymers offer unique applications in sensing and drug delivery.

Purpose of the Study:

  • To synthesize N-Allyl glycine N-carboxyanhydride (NCA) monomer.
  • To polymerize NCA via ring-opening polymerization (ROP) to create novel polypeptoids.
  • To investigate the properties and modification potential of the resulting poly(N-allyl glycine).

Main Methods:

  • Synthesis of N-Allyl glycine N-carboxyanhydride (NCA).
  • Ring-opening polymerization (ROP) of NCA under homo- and heterophase conditions.
  • Characterization of polymer molecular weight (M(W)) and polydispersity index (PDI).
  • Investigation of stimuli-responsive behavior in aqueous solutions.
  • Modification of poly(N-allyl glycine) using thiol-ene photochemistry.

Main Results:

  • Well-defined poly(N-allyl glycine) was successfully synthesized with controlled molecular weights (1.5-10.5 kg mol(-1)) and low polydispersity (1.1-1.4).
  • The synthesized poly(N-allyl glycine) exhibited stimuli-responsive behavior in water.
  • The polymer's allyl side chains were readily functionalized using thiol-ene photochemistry under mild conditions.

Conclusions:

  • N-Allyl glycine NCA is a viable monomer for producing well-defined polypeptoids via ROP.
  • Poly(N-allyl glycine) possesses inherent stimuli-responsive properties and is amenable to post-polymerization modification.
  • The facile modification via thiol-ene chemistry opens avenues for creating functionalized polypeptoid-based materials.