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Electrowetting-based Digital Microfluidics Platform for Automated Enzyme-linked Immunosorbent Assay
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Programmable large area digital microfluidic array with integrated droplet sensing for bioassays.

B Hadwen1, G R Broder, D Morganti

  • 1Sharp Laboratories of Europe, Edmund Halley Road, Oxford Science Park, Oxford, OX4 4GB, UK. ben.hadwen@sharp.co.uk

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|July 13, 2012
PubMed
Summary
This summary is machine-generated.

This study introduces an active matrix electrowetting on dielectric (AM-EWOD) device for digital microfluidics. This novel system offers enhanced control and accuracy for droplet operations, improving assay reliability.

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Area of Science:

  • Microfluidics
  • Biotechnology
  • Electrical Engineering

Background:

  • Conventional electrowetting on dielectric (EWOD) devices face limitations in droplet operation control due to restricted electrical connections.
  • Active matrix electrowetting on dielectric (AM-EWOD) devices utilize thin-film transistor (TFT) arrays for independent electrode control, overcoming these limitations.

Purpose of the Study:

  • To introduce and characterize a novel AM-EWOD device with integrated impedance sensing for digital microfluidics.
  • To demonstrate the device's capability for precise droplet manipulation and assay control.
  • To evaluate the performance of the AM-EWOD device in a biological assay.

Main Methods:

  • Design and fabrication of a 64x64 format AM-EWOD device incorporating impedance sensors.
  • Utilizing TFT arrays for individually addressable electrodes, enabling reconfigurable and simultaneous droplet operations.
  • Implementation of a colorimetric assay for glucose measurement in human blood serum on the AM-EWOD platform.

Main Results:

  • The AM-EWOD device demonstrated independent control over thousands of electrodes, facilitating complex droplet manipulations.
  • Integrated impedance sensors provided accurate droplet detection and sizing, enhancing assay reliability and enabling closed-loop control.
  • Glucose measurements in human blood serum using the AM-EWOD device showed comparable results to traditional microtitre plate assays.

Conclusions:

  • The developed AM-EWOD device represents a significant advancement in digital microfluidics, offering superior control and integrated sensing capabilities.
  • The impedance sensing functionality enhances assay accuracy, reliability, and automation potential.
  • This technology holds promise for various applications in diagnostics and biochemical analysis.