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S100A12 as a marker to predict cardiovascular events in patients with chronic coronary artery disease

Toshinobu Saito1, Yukihiro Hojo, Yukako Ogoyama

  • 1Department of Cardiology, Jichi Medical University, Shimotsuke, Japan.

Circulation Journal : Official Journal of the Japanese Circulation Society
|July 13, 2012
PubMed

Insights

Plasma S100A12 levels can predict major adverse cardiovascular events (MACE) in patients with stable coronary artery disease (CAD). Higher S100A12 levels indicate increased risk, suggesting its potential as a novel biomarker for cardiovascular outcomes.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation

Background:

  • S100A12 is a protein released from white blood cells, implicated in inflammatory cardiovascular disease.
  • Its plasma level is hypothesized to predict outcomes in chronic coronary artery disease (CAD).

Purpose of the Study:

  • To determine the clinical significance of S100A12 in predicting cardiovascular events in patients with stable CAD.

Main Methods:

  • A cohort of 652 patients with stable CAD who underwent percutaneous coronary intervention was studied.
  • Major adverse cardiovascular events (MACE) were tracked over a mean follow-up of 973 days.
  • Plasma S100A12 levels were analyzed for correlation with hs-CRP and prediction of MACE using Kaplan-Meier and Cox models.

Main Results:

  • 16.6% of patients experienced MACE.
  • Plasma S100A12 showed a positive correlation with hs-CRP.
  • Higher S100A12 quartiles were associated with significantly higher MACE rates (P=0.002).
  • S100A12 independently predicted MACE in multivariate analysis, unlike hs-CRP (P=0.074).

Conclusions:

  • S100A12 is a potential novel biomarker for predicting cardiovascular events in patients with stable CAD.
  • Elevated S100A12 levels signify increased risk for MACE.
Abstract

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