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Related Experiment Video

Updated: May 20, 2026

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

Hyperbaric oxygen therapy for vascular dementia.

Yousheng Xiao¹, Jin Wang, Shan Jiang

¹Department of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.

The Cochrane Database of Systematic Reviews

|July 13, 2012

Summary

This summary is machine-generated.

Hyperbaric oxygen therapy (HBOT) may improve cognitive function in vascular dementia (VaD) patients when used with donepezil. However, more high-quality research is needed to confirm HBOT

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Last Updated: May 20, 2026

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

Area of Science:

Neurology
Hyperbaric Medicine
Gerontology

Background:

Hyperbaric oxygen therapy (HBOT) is explored for various conditions.
Preliminary studies suggest potential efficacy for vascular dementia (VaD).

Purpose of the Study:

To evaluate the effectiveness and safety of HBOT for vascular dementia.
To assess HBOT as a standalone or adjuvant therapy for VaD.

Main Methods:

Systematic search of multiple databases including ALOIS, CBM, CNKI, and VIP.
Inclusion criteria: Randomized controlled trials comparing HBOT with no intervention, sham HBOT, or as an add-on therapy.
Data extraction and quality assessment by two independent reviewers.

Main Results:

One low-quality study with 64 patients was included.
HBOT combined with donepezil showed significantly better cognitive function (MMSE, HDS) than donepezil alone after 12 weeks.
No safety data or assessment of global function, behavior, or daily living activities were reported.

Conclusions:

Current evidence is insufficient to support HBOT for vascular dementia treatment.
Future research requires rigorous, randomized, double-blind trials comparing HBOT against sham HBOT.