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[C reactive protein in women with coronary heart disease and its association with depression]

Cora Stefanie Weber1, Kristina Orth-Gomér, Frank Zimmermann-Viehoff

  • 1Charité Universitätsmedizin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin. cora.weber@charite.de

Zeitschrift Fur Psychosomatische Medizin Und Psychotherapie
|July 13, 2012
PubMed

Insights

Depression and inflammation (C-reactive protein) are linked in healthy women but not in women with coronary heart disease (CHD). Further research is needed to understand depression

Area of Science:

  • Cardiovascular Disease Research
  • Psychoneuroimmunology
  • Women's Health

Context:

  • Depression elevates coronary heart disease (CHD) risk and worsens outcomes.
  • Low-grade inflammation is a proposed mechanism, confirmed in men but not women.
  • Investigating inflammation's role in women with CHD is crucial.

Purpose:

  • To examine the association between C-reactive protein (CRP), a biomarker of inflammation, and depressive symptoms in women with CHD.
  • To compare this association in women with CHD versus healthy controls.

Summary:

  • No significant association was found between depressive symptoms and CRP in women with CHD.
  • Healthy women with more depressive symptoms showed heightened CRP levels.
  • Women with CHD exhibited higher CRP and more depressive symptoms than controls.

Impact:

  • Findings suggest the link between depression and inflammation may differ in women with CHD compared to healthy women.
  • Highlights the need for further research into depression's mechanisms in women's cardiovascular health.
  • Contributes to understanding gender-specific pathways in cardiovascular disease.
Abstract

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