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Related Concept Videos

Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Nuclear Export of mRNA02:31

Nuclear Export of mRNA

Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
Nuclear Export of mRNA02:31

Nuclear Export of mRNA

Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
Nuclear Export01:42

Nuclear Export

The nucleus restricts several proteins within and allows others to pass. The restricted proteins possess a nuclear retention sequence or NRS, anchoring them to the nuclear lamins and preventing their transport to the cytosol. The non-restricted proteins, after their synthesis, are transported to their site of action, such as the cytosol or other organelles, with the help of nuclear export signals or NES.
NES are of three types- the canonical 10-residue long leucine-rich signal and other...
Intracellular Hormone Receptors01:08

Intracellular Hormone Receptors

Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell

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Related Experiment Video

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Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

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Published on: March 17, 2016

Transcriptomine, a web resource for nuclear receptor signaling transcriptomes.

Scott A Ochsner1, Christopher M Watkins, Apollo McOwiti

  • 1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

Physiological Genomics
|July 13, 2012
PubMed
Summary
This summary is machine-generated.

This study introduces Transcriptomine, a database that integrates and annotates vast transcriptomic data for nuclear receptors (NRs). It enables researchers to easily query and analyze NR signaling pathways for hypothesis generation and validation.

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Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
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Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets
03:37

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets

Published on: March 1, 2024

Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • Nuclear receptors (NRs) are crucial transcription factors regulating diverse biological processes.
  • Existing transcriptomic data for NRs is fragmented, hindering comprehensive analysis.
  • Lack of accessibility, annotation, and integration limits the full potential of NR research.

Purpose of the Study:

  • To create a centralized, searchable database of NR-related transcriptomic data.
  • To facilitate the integration and analysis of disparate gene expression datasets.
  • To empower researchers with a tool for hypothesis generation and validation in NR signaling.

Main Methods:

  • Systematic search of public gene expression databases and MEDLINE for NR transcriptomic datasets.
  • Deep reannotation of datasets using controlled vocabularies for RNA Source and regulating molecule.
  • Assembly of curated data into the Transcriptomine database with advanced querying capabilities.

Main Results:

  • Transcriptomine integrates millions of previously disparate transcriptomic data points.
  • The database allows flexible querying by genes, Gene Ontology terms, disease terms, and custom lists.
  • Users can modify experimental variables and download data for downstream analysis.

Conclusions:

  • Transcriptomine serves as a powerful resource for mining NR signaling biology.
  • The database facilitates hypothesis generation and validation through in silico and experimental approaches.
  • Transcriptomine is poised to become an essential tool for NR and signal transduction research communities.