Iontophoresis with an adrenergic alpha-blocker in acoustic overstimulation

To study the influence of sympathetic innervation on the amount of threshold shift (TS) induced by sound overstimulation, iontophoresis with phentolamine, a known adrenergic alpha-blocker, was performed on awake guinea pigs. The sound exposure following this induced a significantly lesser degree of TS when compared with the control group. These findings indicate that iontophoresis may be of great help in transporting specific ionized chemical compounds through the intact cochlear walls in a completely non-invasive manner for studying cochlear physiology.