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Is there any correlation between hypercalciuria and nocturnal enuresis?
A Nikibakhsh1, H Poostindooz, H Mahmoodzadeh
1Department of Pediatric Nephrology, Urmia University of Medical Sciences, Urmia, Iran.
Indian Journal of Nephrology
|July 13, 2012
Summary
Hypercalciuria, or high calcium in urine, is more common in children with nocturnal enuresis (bedwetting) than in healthy children. Measuring urine calcium may help identify causes of bedwetting.
Area of Science:
- Pediatrics
- Nephrology
- Urology
Background:
- Nocturnal enuresis is a prevalent childhood issue.
- Hypercalciuria is a potential contributing factor to bedwetting.
Purpose of the Study:
- To determine the incidence of hypercalciuria in children experiencing nocturnal enuresis.
- To compare hypercalciuria rates between enuretic children and healthy controls.
Main Methods:
- A case-control study involving 118 children with nocturnal enuresis and 100 matched healthy controls.
- Urine samples collected upon waking and 2 hours later to measure calcium/creatinine ratios.
- Serum calcium, phosphorus, electrolytes, and PTH levels assessed in hypercalciuric individuals.
Main Results:
- The mean urine calcium/creatinine ratio was significantly higher in the nocturnal enuresis group (0.070±0.06 mg/mg) compared to controls (0.050±0.046 mg/mg; P=0.008).
- Hypercalciuria was detected in 12/118 children with nocturnal enuresis versus 3/100 controls (P=0.032).
- All hypercalciuric subjects exhibited normal serum calcium, phosphorus, electrolyte, and PTH levels.
Conclusions:
- A significantly higher frequency of hypercalciuria exists in children with nocturnal enuresis.
- Measurement of urinary calcium is recommended for children presenting with nocturnal enuresis to explore potential etiologies.
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