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Recombinant activated factor VII for diffuse alveolar hemorrhage in microscopic polyangiitis

S K Mandal1, G Sagar, M Sahoo

  • 1Department of Nephrology, Indraprastha Apollo Hospital, New Delhi, India.

Indian Journal of Nephrology
|July 13, 2012
PubMed

Diffuse alveolar hemorrhage is a serious complication of the small vessel vasculitis syndromes and carries a high mortality. Recombinant activated factor VII (rFVIIa) is a powerful hemostatic agent developed for treatment of bleeding in patients with hemophilia and antibodies to factors VIII or IX. It has been used increasingly in life-threatening hemorrhage in a variety of other settings in which conventional medical or surgical therapy is unsuccessful. We report the successful use of rFVIIa for massive pulmonary hemorrhage in a patient of microscopic polyangiitis, which was later complicated by thrombotic microangiopathy and posterior reversible encephalopathy syndrome.

Keywords:
Diffuse alveolar hemorrhagemicroscopic polyangiitisposterior reversible encephalopathy syndromerecombinant factor VIIathrombotic microangiopathy

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