Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for their...
The Blood-brain Barrier00:49

The Blood-brain Barrier

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Supernatant of Water Extraction-Ethanol Precipitation of <i>Chaga mushroom</i> Improves Hyperglycemia in Type 2 Diabetes Mellitus and Is Accompanied by Changes in Gut Microbiota Composition.

Foods (Basel, Switzerland)·2026
Same author

Optimal substrate composition (C, N, and trace metals) for liquid culture of <i>Akanthomyces attenuatus</i> JEF 147 isolate.

Frontiers in fungal biology·2026
Same author

Mathematical modeling with RGB data for comparative analysis of rice lineages and distribution of breaking points.

BMC plant biology·2026
Same author

Early Flowering (<i>ELF</i>) Gene Integrates Vegetative Growth, Flowering Regulation, and Reproductive Development in <i>Arabidopsis thaliana</i>.

International journal of molecular sciences·2026
Same author

Targeting IDH-Mutant Glioma with Vorasidenib : A New Era in Precision Neuro-Oncology.

Journal of Korean Neurosurgical Society·2026
Same author

Identification of a UDP-glucuronosyl/UDP-glucosyltransferase involved in rice seedling height regulation.

BMC plant biology·2026

Related Experiment Video

Updated: May 20, 2026

An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke
12:19

An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke

Published on: March 11, 2018

Ginkgo biloba extract (EGb 761) prevents the ischemic brain injury-induced decrease in parvalbumin expression.

Jin-Hee Sung1, Fawad-Ali Shah, Eun-Hae Cho

  • 1Department of Anatomy, College of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, Jinju, Korea.

Laboratory Animal Research
|July 13, 2012
PubMed
Summary

Ginkgo biloba extract (EGb 761) protects the brain from ischemic injury by maintaining parvalbumin expression. This neuroprotective effect involves preserving parvalbumin levels, crucial for calcium buffering and preventing cell death.

Keywords:
EGb 761neuroprotectionparvalbumin

More Related Videos

Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method
10:53

Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method

Published on: February 26, 2018

Related Experiment Videos

Last Updated: May 20, 2026

An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke
12:19

An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke

Published on: March 11, 2018

Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method
10:53

Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method

Published on: February 26, 2018

Area of Science:

  • Neuroscience
  • Pharmacology
  • Biochemistry

Background:

  • Ischemic brain injury triggers cell death pathways, including apoptosis.
  • Parvalbumin, a calcium-binding protein, is vital for neuronal function and survival.
  • Ginkgo biloba extract (EGb 761) is known for its neuroprotective properties.

Purpose of the Study:

  • To investigate the effect of EGb 761 on parvalbumin expression following cerebral ischemic injury.
  • To determine if EGb 761's neuroprotective mechanism involves modulating parvalbumin levels.

Main Methods:

  • Middle cerebral artery occlusion (MCAO) model in adult male Sprague-Dawley rats.
  • Treatment with vehicle or EGb 761 (100 mg/kg) prior to MCAO.
  • Proteomic analysis, RT-PCR, Western blot, and immunohistochemical staining to assess parvalbumin expression.

Main Results:

  • MCAO induced a significant decrease in parvalbumin expression in vehicle-treated rats.
  • EGb 761 pretreatment attenuated the MCAO-induced reduction in parvalbumin expression.
  • Immunohistochemistry confirmed a lower number of parvalbumin-positive cells in MCAO rats, an effect reversed by EGb 761.

Conclusions:

  • EGb 761 preserves parvalbumin expression in the context of ischemic brain injury.
  • Maintenance of parvalbumin levels is associated with the neuroprotective effects of EGb 761 against ischemia.
  • EGb 761 may exert its anti-apoptotic neuroprotection by regulating parvalbumin-dependent calcium homeostasis.