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Ischemic stroke in Takayasu's arteritis: lesion patterns and possible mechanisms
Jaechun Hwang1, Suk Jae Kim, Oh Young Bang
1Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Journal of Clinical Neurology (Seoul, Korea)
|July 13, 2012
Summary
Takayasu
Area of Science:
- Neurology
- Cardiology
- Radiology
Background:
- Takayasu's arteritis (TA) is a rare, chronic inflammatory disease affecting large arteries.
- Cerebrovascular events, including ischemic stroke, are a significant complication of TA.
Purpose of the Study:
- To investigate the underlying mechanisms of stroke in patients diagnosed with Takayasu's arteritis.
- Utilize brain magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) for stroke mechanism identification.
Main Methods:
- Retrospective analysis of 190 Takayasu's arteritis patients.
- Inclusion of 21 patients with acute cerebral infarctions for detailed lesion pattern analysis.
- Evaluation of patient characteristics, infarction patterns, and degree of cerebral artery stenosis.
Main Results:
- 21 ischemic stroke events were identified in the study cohort.
- Large lobar and large deep infarctions were the most frequent lesion types (33.3% each).
- Magnetic resonance angiography (MRA) indicated intracranial artery stenosis in 11 patients.
Conclusions:
- Hemodynamic compromise due to large artery stenosis is a key factor in TA-related strokes.
- Thromboembolic mechanisms also contribute significantly to ischemic stroke in Takayasu's arteritis patients.
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