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Related Concept Videos

Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Drug Regulation01:25

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...

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Related Experiment Video

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Field Identification of Matricaria chamomilla using a Portable qPCR System
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Published on: October 10, 2020

Herbal medicines--a cautionary tale.

Sophie Gray1, Lance M West

  • 1School of Dentistry, The University of Otago, Dunedin. sophieg@xtra.co.nz

The New Zealand Dental Journal
|July 14, 2012
PubMed
Summary
This summary is machine-generated.

A patient experienced significant intra-operative bleeding during orthognathic surgery, potentially linked to taking the herbal medicine arnica. This highlights the importance of inquiring about herbal remedies during patient history to prevent surgical complications.

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Area of Science:

  • Oral and Maxillofacial Surgery
  • Pharmacology
  • Herbal Medicine Interactions

Background:

  • Orthognathic surgery is a complex procedure often requiring careful management of potential complications.
  • Patient history taking is crucial for identifying risk factors, including medication and supplement use.
  • Herbal medicines are increasingly used by patients, but their peri-operative effects are not always well-understood.

Observation:

  • A patient undergoing orthognathic surgery experienced substantial intra-operative hemorrhage (approximately 3.5 liters).
  • Preoperative laboratory tests were unremarkable, and the patient reported no prescription medication use.
  • The patient had taken the herbal medicine arnica the day prior to the surgical procedure.

Findings:

  • Arnica, a commonly used herbal supplement, may be associated with an increased risk of bleeding during surgical procedures.
  • The literature review indicates that herbal medicines can contribute to unexplained surgical bleeding when other causes are absent.
  • Clinicians should be aware of potential hemostatic challenges posed by herbal remedies.

Implications:

  • Inquiring about herbal remedy use should be a standard part of the pre-surgical patient assessment, particularly for dental and maxillofacial procedures.
  • Enhanced awareness and documentation of herbal medicine consumption can aid in preventing and managing peri-operative bleeding events.
  • Further research into the specific mechanisms and clinical significance of herbal medicine interactions with surgical hemostasis is warranted.