Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacovigilance

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...

Vaccinations

Vaccinations

Hypersensitivity Reactions: Immune-Complex Reactions

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...

Drug Toxicity: Allergic Reactions

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Vaccination policies for healthcare personnel in Europe, 2026.

Vaccine·2026

Same author

Clinical features, disease severity, and outcomes of pertussis in hospitalized children: A retrospective study from Serbia.

PloS one·2026

Same author

Determinants of seat belt use among drivers: a BRFSS study from a middle-income country (Vojvodina, Serbia).

Frontiers in public health·2026

Same author

Differential Therapeutic Modulations of Adiponectin: Beneficial, Adverse, and Context-Dependent Effects in Chronic Coronary Syndromes.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre·2026

Same author

Predictors of binge drinking among adults in Autonomous Province of Vojvodina, Serbia: Data from the population-based behavioral risk-factors surveillance system.

PloS one·2026

Same author

Vaccine-preventable disease outbreaks in schools, part 2: pertussis, meningococcal disease, diphtheria, poliomyelitis, hepatitis A, and rotavirus infection.

Vaccine·2026

Search research articles

Related Experiment Video

Updated: May 20, 2026

Intracranial Injection of Adeno-associated Viral Vectors

Intracranial Injection of Adeno-associated Viral Vectors

Published on: November 17, 2010

[Adverse events due to the immunization--case report].

Snezana Medic¹, Vladimir Petrović

¹Zavod za javno zdravlje Sremska Mitrovica. snezanamedic@gmail.com

Medicinski Pregled

|July 14, 2012

Summary

Adverse events after immunization require careful assessment by expert teams. Collaborative medical evaluation ensures appropriate decisions regarding future vaccinations for children, balancing risks and benefits.

Related Experiment Videos

Last Updated: May 20, 2026

Intracranial Injection of Adeno-associated Viral Vectors

Intracranial Injection of Adeno-associated Viral Vectors

Published on: November 17, 2010

Area of Science:

Pediatric Allergy and Immunology
Vaccinology
Public Health

Background:

Adverse events following immunization (AEFI) are medical incidents that can occur after vaccination.
AEFI assessment involves evaluating vaccine reactions, handling errors, or coincidental events.
Regional expert teams determine the severity of reactions and contraindications for future immunization.

Observation:

A case series details adverse events in three siblings following vaccination between 2007 and 2010.
All three children experienced diverse, severe events requiring hospitalization.
The siblings shared a personal and family history of atopic diseases, and underwent comprehensive allergological/immunological testing.

Findings:

Despite varied and severe events, two of the three siblings completed their vaccination series on time.
Effective collaboration among general practitioners, pediatricians, and expert teams facilitated timely vaccination.
Decision-making for subsequent immunization hinges on the event's nature, severity, medical evaluation, and individual risk assessment.

Implications:

Close cooperation among healthcare professionals and experts is crucial for managing AEFIs.
Informed decisions on immunization are vital for maintaining individual and community immunity.
Personalized risk-benefit analysis guides immunization strategies in children with a history of adverse events.