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Related Experiment Video

Updated: May 20, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Immunotherapy for polyomaviruses: opportunities and challenges.

Tina Dalianis¹

¹Department of Oncology-Pathology, Karolinska Institute, Cancer Center Karolinska, Karolinska University Hospital, SE-171 76 Stockholm, Sweden. tina.dalianis@ki.se

|July 14, 2012

Summary

Human polyomaviruses (HPyVs) are common but usually harmless. This review discusses HPyV-associated diseases in immunosuppressed individuals and explores VP1 virus-like particles as potential vaccines.

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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

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Published on: May 27, 2011

Area of Science:

Virology
Immunology
Vaccinology

Background:

Polyomaviruses are ubiquitous DNA viruses found in mammals and birds.
The first human polyomaviruses (HPyVs), BK virus and JC virus, were discovered in 1971.
Since 2007, seven new HPyVs have been identified, increasing our understanding of their prevalence and impact.

Purpose of the Study:

To review the diseases caused by polyomaviruses, particularly in immunosuppressed individuals.
To explore the potential of using the viral capsid protein VP1 to create virus-like particles (VLPs) for vaccine development against HPyV infections.

Main Methods:

Literature review of polyomavirus research.
Analysis of clinical associations between HPyVs and diseases.
Evaluation of VP1 protein's potential for VLP formation and vaccine applications.

Main Results:

Merkel cell polyomavirus is linked to Merkel cell carcinoma, predominantly in elderly and immunocompromised individuals.
Trichodyplasia spinulosa polyomavirus is associated with a skin disorder in immunosuppressed patients.
Many HPyVs cause significant health issues in individuals with weakened immune systems.

Conclusions:

Polyomaviruses pose a threat to immunosuppressed populations, causing various diseases.
The VP1 protein shows promise for developing effective virus-like particle vaccines against polyomavirus infections.