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Updated: May 20, 2026

Sample Preparation for Probe Electrospray Ionization Mass Spectrometry

Sample Preparation for Probe Electrospray Ionization Mass Spectrometry

Published on: February 19, 2020

Electrochemical push-pull scanner with mass spectrometry detection.

Dmitry Momotenko¹, Liang Qiao, Fernando Cortés-Salazar

¹Laboratoire d'Electrochimie Physique et Analytique, Ecole Polytechnique Fédérale de Lausanne, Station 6, CH-1015 Lausanne, Switzerland.

Analytical Chemistry

|July 14, 2012

Summary

This summary is machine-generated.

This study introduces a novel scanner for analyzing dry surfaces using scanning electrochemical microscopy (SECM) and mass spectrometry (MS). It successfully imaged latent fingerprints and enzyme activity, demonstrating a powerful new analytical technique.

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Applications of the Single-probe: Mass Spectrometry Imaging and Single Cell Analysis under Ambient Conditions

Applications of the Single-probe: Mass Spectrometry Imaging and Single Cell Analysis under Ambient Conditions

Published on: June 14, 2016

Area of Science:

Analytical Chemistry
Surface Science
Electrochemistry

Background:

Characterizing dry surfaces requires advanced analytical methods.
Integrating electrochemical and mass spectrometry techniques offers synergistic analytical capabilities.

Purpose of the Study:

To develop and demonstrate a push-pull electrochemical scanner for simultaneous surface reactivity imaging and molecular detection.
To validate the system's performance using fingerprint analysis and enzyme activity assays.

Main Methods:

Coupling scanning electrochemical microscopy (SECM) with matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS).
Coupling SECM with electrospray ionization mass spectrometry (ESI-MS).
Utilizing 3D finite element simulations to optimize the integrated system.

Main Results:

Successfully imaged latent human fingerprints exposed to a model explosive (picric acid) using SECM-MALDI-MS.
Assayed the activity of surface-spotted enzymes using SECM-ESI-MS.
Simulations provided insights for optimizing the scanner's performance.

Conclusions:

The developed push-pull electrochemical scanner is effective for analyzing dry surfaces.
This integrated approach enables sensitive molecular probing and reactivity imaging.
The technology holds potential for forensic science and biochemical analysis.