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Updated: May 20, 2026
Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
The effect of timing of embryonic progression on chromosomal abnormality
Lindsay Kroener1, Gayane Ambartsumyan, Christine Briton-Jones
1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California, Los Angeles, California 90095, USA.
Objective:
To evaluate the relationship between aneuploidy and timing of blastocyst formation.
Design:
Historical cohort study.
Setting:
Private IVF clinic.
Patient(S):
Ninety-four couples undergoing IVF treatment in combination with chromosomal screening of embryos. The mean maternal age was 39.2 years and average number of embryos per patient 5.3.
Intervention(S):
A total of 530 embryos were biopsied on day 3 and underwent chromosome screening with microarray-based comparative genomic hybridization.
Main Outcome Measure(S):
Effect of day of embryo blastulation and morphologic grade on aneuploidy rate.
Result(S):
Day 5 morulas that progressed to blastocysts on day 6 were significantly less likely to be aneuploid (79.8%) than day 5 morulas that did not progress to blastocysts (92.9%). However, there was no significant difference in aneuploidy rates when embryos that became blastocysts on day 5 were directly compared with embryos that became blastocysts on day 6.
Conclusion(S):
Delayed blastulation is not associated with increased aneuploidy rates, but absence of blastulation is associated with increased aneuploidy. Therefore, we conclude that when choosing a morula for transfer on day 5, there may be a benefit in waiting an extra day for the possibility of blastulation to occur.
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