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The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Related Experiment Video

Updated: May 20, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

Wilms tumor.

Andrew M Davidoff¹

¹Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA. andrew.davidoff@stjude.org

Advances in Pediatrics

|July 14, 2012

Summary

This summary is machine-generated.

New Wilms tumor treatment protocols improve cure rates in children while reducing side effects. These advancements stem from refined risk-stratification systems for better patient outcomes.

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Last Updated: May 20, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

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Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts

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Published on: May 25, 2018

Area of Science:

Pediatric Oncology
Nephrology
Clinical Trials

Background:

Wilms tumor is a common kidney cancer in children.
Previous treatment protocols have varying success rates and toxicity profiles.
Risk-stratification is crucial for tailoring therapy.

Purpose of the Study:

To introduce and evaluate novel treatment protocols for pediatric Wilms tumor.
To enhance cure rates in affected children.
To minimize treatment-related toxicity through refined risk assessment.

Main Methods:

Implementation of updated treatment protocols based on risk stratification.
Close monitoring of patient response and adverse events.
Analysis of cure rates and toxicity levels.

Main Results:

Significant improvements observed in the treatment of pediatric Wilms tumor.
High cure rates achieved in patients undergoing new protocols.
Minimized toxicity levels reported, enhancing patient safety and quality of life.

Conclusions:

Refined risk-stratification systems have led to superior Wilms tumor treatment outcomes.
New protocols effectively balance high cure rates with reduced toxicity.
These advancements represent a significant step forward in pediatric oncology care.