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Karyotypic changes identified by HaeIII restriction endonuclease banding in a patient with M2 acute non-lymphoblastic
L Stuppia1, G Palka, G Fioritoni
1Institute of Biology and Genetics, University of Chieti, Italy.
Genes, Chromosomes & Cancer
|March 1, 1990
Abstract:
A patient with acute non-lymphoblastic leukemia, FAB type M2, showed a complex karyotype involving chromosomes 1 and 11. The breakpoints could not be exactly identified by GTG and QFQ banding. A subsequent analysis with Alul and HaeIII restriction enzyme staining allowed the detection of a translocation of the heterochromatic region of chromosome 1 to 11q21.