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Related Experiment Video

Updated: May 20, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

[Neuromyelitis optica in children. Two case reports].

B Tosello1, C Halbert, J Mancini

  • 1Service de neurologie pédiatrique, CHU La Timone, Assistance publique-Hôpitaux de Marseille, 264, rue Saint-Pierre, 13005 Marseille, France. barthelemy.tosello@ap-hm.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|July 14, 2012
PubMed
Summary

Devic neuromyelitis optica (NMO) is an autoimmune disorder distinct from multiple sclerosis, identified by specific aquaporin-4 antibodies. High antibody affinity was observed in a patient without brain symptoms, highlighting NMO

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Area of Science:

  • Neurology
  • Immunology
  • Neuroinflammation

Background:

  • Devic neuromyelitis optica (NMO) is a CNS inflammatory demyelinating disease characterized by optic neuritis and transverse myelitis.
  • NMO is distinct from multiple sclerosis, with aquaporin-4 (AQP4) antibodies serving as a specific serological marker.
  • Brain lesions on MRI do not exclude NMO, particularly in areas rich in AQP4 channels.

Observation:

  • This report details two cases of NMO associated with anti-AQP4 antibodies.
  • One patient presented without symptomatic brain involvement, yet exhibited high anti-NMO antibody affinity for AQP4.
  • Flow cytometry was utilized to assess antibody affinity in the observed cases.

Findings:

  • The presence of anti-AQP4 antibodies is a key diagnostic marker for NMO.

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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

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Last Updated: May 20, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

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  • High antibody affinity for AQP4 can be present even in the absence of overt brain symptoms.
  • Brain lesion location in NMO can overlap with AQP4-rich areas.

    • Implications:

    • Understanding the role of AQP4 antibodies is crucial for accurate NMO diagnosis and differentiation from MS.
    • High antibody affinity may indicate specific disease mechanisms or prognostic factors in NMO.
    • Effective treatment strategies for NMO, such as rituximab, are vital for patients unresponsive to corticosteroids.